What is Neurontin?

The essence of Neurontin (gabapentin) lies in its ability to provide relief and management for certain medical conditions. Neurontin is primarily used to control seizures in epilepsy and alleviate neuropathic pain caused by nerve damage or dysfunction.

For individuals with epilepsy, it helps reduce the occurrence and severity of seizures, allowing for improved quality of life and increased seizure control. It can be especially beneficial for individuals who have partial seizures or those who experience neuropathic pain alongside their seizures.

Neurontin’s essence extends to its effectiveness in managing neuropathic pain. Conditions such as diabetic neuropathy, postherpetic neuralgia, and peripheral neuropathy can cause debilitating nerve pain, often characterized by burning, shooting, or tingling sensations. This drug works to modulate neurotransmitters and calcium channels in the central nervous system, providing relief from these neuropathic pain symptoms.


Neurontin (gabapentin) is classified as an anticonvulsant or antiepileptic drug (AED). It is primarily used to manage seizures associated with epilepsy. Additionally, it is classified as a nerve pain medication or analgesic for the treatment of neuropathic pain, which refers to pain caused by nerve damage or dysfunction. It is believed to modulate the activity of certain neurotransmitters and calcium channels in the central nervous system, contributing to its anticonvulsant and analgesic effects. This preparation is available in oral capsule, tablet, and oral solution formulations.

What is Neurontin generic name?

The generic name for Neurontin is gabapentin. Gabapentin is the active ingredient and is available in various generic formulations produced by different pharmaceutical manufacturers. Generic gabapentin is considered bioequivalent to the brand-name Neurontin, meaning it has the same active ingredient, strength, dosage form, and intended use.

What is Neurontin used for?

Neurontin (gabapentin) is used for the treatment of various medical conditions. It is primarily prescribed to manage seizures (epilepsy) and relieve neuropathic pain. Neuropathic pain refers to pain caused by nerve damage or dysfunction, often associated with conditions such as diabetic neuropathy, postherpetic neuralgia (nerve pain following shingles), and peripheral neuropathy.

Additionally, it may be used off-label (i.e., for conditions not specifically approved by regulatory authorities) to manage other types of chronic pain, such as fibromyalgia, trigeminal neuralgia, and certain types of migraines. It can also be considered as an adjuvant therapy for individuals with refractory partial seizures or as an alternative treatment option when other medications are ineffective or poorly tolerated.

Furthermore, Neurontin has shown some effectiveness in treating certain psychiatric and neurological disorders, including bipolar disorder, restless legs syndrome, social anxiety disorder, and alcohol withdrawal symptoms.

How does Neurontin work?

The mechanism of action of Neurontin (gabapentin) is not fully understood, but it is believed to involve several potential mechanisms that contribute to its therapeutic effects. While the exact mode of action is still being investigated, here are some key aspects of the mechanism:

  1. Calcium Channel Modulation: It binds to specific sites on voltage-gated calcium channels, particularly the α2δ subunit. By binding to these channels, this medicine reduces the influx of calcium ions into neurons, which may help regulate neuronal excitability and reduce the release of certain neurotransmitters.
  2. Increased GABA Availability: It may enhance the synthesis and release of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain. By increasing GABA availability, it  may facilitate inhibitory processes and help modulate neuronal activity.
  3. Glutamate Regulation: The drug has been suggested to affect the release and metabolism of the excitatory neurotransmitter glutamate. It may reduce the release of glutamate and modulate its effects, thereby contributing to its anticonvulsant and analgesic properties.
  4. Other Mechanisms: The drug may also have interactions with other neurotransmitter systems, such as adenosine receptors, and influence neuronal signaling pathways involved in pain modulation.

How long does it take Neurontin to work?

The onset of action and the time it takes for Neurontin (gabapentin) to work can vary among individuals and depend on several factors, including the condition being treated and the individual’s response. While there is no definitive answer, here are some general considerations:

  1. Immediate Effects: This drug may start exerting its effects soon after ingestion, with some individuals reporting initial relief within a few hours or even sooner.
  2. Gradual Improvement: In many cases, the therapeutic effects may take some time to fully develop. It can require consistent use of the medication over several days or weeks to observe significant improvements in symptoms.
  3. Titration Period: It is often initiated at a low dose and gradually increased to the optimal therapeutic dose. This titration period allows the body to adjust to the medication, and the full benefits may not be experienced until the target dosage is reached.
  4. Individual Response: Each person’s response to Neurontin can be unique. Some individuals may experience noticeable relief relatively quickly, while others may require a longer duration before experiencing the desired therapeutic effects.

How long does Neurontin stay in your system?

The duration that Neurontin (gabapentin) remains in the system can vary depending on several factors, including the individual’s metabolism, dosage, frequency of administration, and other individual characteristics. While there is no exact answer, here are some general considerations:

  1. Elimination Half-Life: Neurontin has an elimination half-life of approximately 5 to 7 hours in individuals with normal kidney function. This means that it takes about 5 to 7 hours for half of the medication to be cleared from the body.
  2. Steady State: It typically takes around five times the elimination half-life for a medication to reach steady state, where the drug has accumulated to a consistent level in the body. For Neurontin, it may take around 1 to 2 days to achieve steady-state concentrations.
  3. Duration of Effect: The therapeutic effects may last beyond its elimination half-life. The pain-relieving or anticonvulsant effects can persist for several hours or even longer after each dose.
  4. Individual Variations: Individual variations in metabolism, liver and kidney function, and other factors can influence how long this substance stays in the system. Some individuals may metabolize and eliminate the medication more quickly or slowly than others.

What is the dosage?

The dosage of Neurontin (gabapentin) can vary depending on the condition being treated, individual patient factors, and the healthcare provider’s recommendation. The minimum and maximum dosages can differ based on the specific indication. It’s important to note that dosages should always be determined by a healthcare professional.

Minimum Dosage: The minimum dosage of Neurontin typically starts at a low initial dose and gradually increases over time to achieve the desired therapeutic effect. The minimum effective dose can vary depending on the condition being treated, but it is typically in the range of 300 to 900 milligrams per day, divided into two or three doses.

Maximum Dosage: The maximum dosage of Neurontin also varies depending on the condition and individual response. For epilepsy, the maximum recommended daily dosage can range from 1,800 to 3,600 milligrams, divided into three doses. For neuropathic pain, the maximum recommended daily dosage can range from 1,800 to 3,600 milligrams, typically divided into three doses.


An overdose of Neurontin (gabapentin) can lead to various symptoms that may vary in severity. It’s crucial to seek immediate medical attention if an overdose is suspected. Here are some possible signs and symptoms of an overdose:

  1. Excessive Sedation: Profound drowsiness, extreme sleepiness, or difficulty staying awake can be observed in cases of the overdose.
  2. Severe Dizziness: Feeling lightheaded or experiencing an intense spinning sensation that affects balance and coordination.
  3. Respiratory Depression: Slowed or shallow breathing, which can be a serious and potentially life-threatening symptom.
  4. Altered Mental Status: Confusion, disorientation, or impaired cognitive function may occur as a result of the overdose.
  5. Unusual Fatigue: Overwhelming tiredness or extreme lethargy beyond what is expected from the therapeutic dosage.
  6. Gastrointestinal Distress: Nausea, vomiting, stomach pain, or diarrhea may be present in cases of the overdose.
  7. Cardiac Irregularities: In some rare instances, an overdose of Neurontin can lead to abnormal heart rhythms or cardiac complications.

What are contraindications?

While Neurontin (gabapentin) is generally well-tolerated, there are certain contraindications or situations where its use may not be recommended. Here are some strict contraindications associated with this drug:

  1. Hypersensitivity: It should not be used in individuals who have a known hypersensitivity or allergy to gabapentin or any of its components. If you have experienced an allergic reaction to Neurontin or similar medications in the past, it’s important to avoid its use.
  2. Severe Renal Impairment: This drug is primarily eliminated from the body through the kidneys. Therefore, caution should be exercised in individuals with severe renal impairment (creatinine clearance less than 30 mL/min). Dosage adjustments or alternative treatment options may be necessary.

What are the side effects?

Common side effects (may affect 1 in 10 people or more):

  1. Drowsiness: Feeling sleepy or tired;
  2. Dizziness: A sensation of spinning or lightheadedness;
  3. Fatigue: Generalized feeling of tiredness or lack of energy;
  4. Peripheral Edema: Swelling of the hands, feet, or ankles;
  5. Tremor: Involuntary shaking or trembling movements;
  6. Ataxia: Lack of coordination or unsteadiness;
  7. Nystagmus: Involuntary rapid eye movements;
  8. Viral Infections: Increased susceptibility to viral infections such as upper respiratory tract infections.

Uncommon side effects (may affect less than 1 in 10 people):

  1. Mood changes: Including anxiety, depression, or irritability;
  2. Confusion: Difficulty thinking clearly or experiencing cognitive impairment;
  3. Gastrointestinal disturbances: Nausea, vomiting, constipation, or diarrhea;
  4. Dry mouth: Reduced saliva production leading to a dry sensation in the mouth;
  5. Weight gain: Mild to moderate weight gain may occur in some individuals;
  6. Visual disturbances: Blurred vision or double vision;
  7. Skin reactions: Rash or itching.

What are drug interactions?

Neurontin (gabapentin) can interact with certain medications, and it’s important to be aware of these potential interactions. Here are examples of possible drug interactions:

  1. Opioids: Concurrent use of Neurontin with opioids can increase the risk of central nervous system depression, respiratory depression, and sedation. Caution is advised, and dosage adjustments may be necessary.
  2. CNS Depressants: Combining Neurontin with other central nervous system (CNS) depressants, such as benzodiazepines, sedatives, or alcohol, may enhance the sedative effects and increase the risk of drowsiness, dizziness, and impaired coordination.
  3. Antacids: Certain antacids containing aluminum or magnesium hydroxide can reduce the absorption of this drug. To ensure optimal absorption, it is recommended to separate the administration of Neurontin and antacids by at least 2 hours.

What are withdrawal symptoms?

Abrupt discontinuation or rapid withdrawal of Neurontin (gabapentin) after prolonged use can potentially lead to withdrawal-like symptoms in some individuals. These symptoms may vary in intensity and duration and can include:

  1. Rebound Symptoms: The original condition for which Neurontin was prescribed, such as seizures or neuropathic pain, may resurface or worsen temporarily after discontinuing the medication abruptly.
  2. Anxiety and Mood Changes: Some individuals may experience heightened anxiety, irritability, mood swings, or even symptoms of depression during Neurontin withdrawal.
  3. Insomnia or Sleep Disturbances: Discontinuing the described drug abruptly can disrupt sleep patterns, leading to difficulty falling asleep, staying asleep, or experiencing restless nights.
  4. Gastrointestinal Issues: Digestive problems like nausea, vomiting, diarrhea, or stomach discomfort have been reported during the withdrawal.
  5. Physical Discomfort: Headaches, dizziness, lightheadedness, fatigue, muscle aches, and general malaise may occur as part of the withdrawal process.

Gabapentin vs Neurontin

Gabapentin and Neurontin are actually the same medication, with Neurontin being the brand name for the generic drug gabapentin. Therefore, they contain the same active ingredient and have the same mechanism of action, therapeutic effects, and safety profile.

However, there can be some differences in how they are marketed, priced, and available in different regions. Neurontin is the brand name version that was initially marketed by the pharmaceutical company Pfizer. When the patent for Neurontin expired, generic versions of gabapentin became available, which are often sold under their generic names.

While the active ingredient is identical, there may be some variations in the inactive ingredients used in the formulation of generic gabapentin products. These differences are generally considered to have minimal impact on the medication’s overall effectiveness.

In terms of effectiveness and safety, both Neurontin and generic gabapentin have been extensively studied and approved for similar indications, such as epilepsy, neuropathic pain, and other conditions.

Neurontin pricing

Here are some historically known average retail prices for Neurontin (gabapentin) in the United States based on available information:

  • Prior to the availability of generic versions, branded Neurontin could cost around $300 to $400 for a 90-capsule supply (300 mg dosage).
  • After the introduction of generic gabapentin, the prices have generally decreased. Generic gabapentin can range from approximately $15 to $50 for a 90-capsule supply (300 mg dosage) depending on the pharmacy and any applicable discounts or insurance coverage.

Please keep in mind that these prices are approximate and can vary significantly based on factors such as dosage strength, quantity, pharmacy location, discounts, and insurance coverage. Additionally, medication prices can change over time, so it’s best to check with local pharmacies or online resources for the most current pricing information.


Q: Is Neurontin addictive?

A: Neurontin (gabapentin) is generally considered to have a low potential for addiction or abuse. It is not classified as a controlled substance by the U.S. Drug Enforcement Administration (DEA). However, it’s worth noting that there have been reports of this drug’s misuse and abuse in certain individuals, particularly those with a history of substance abuse.

While Neurontin itself is not considered highly addictive, abrupt discontinuation or sudden high-dose reductions after prolonged use may lead to withdrawal-like symptoms, such as anxiety, insomnia, nausea, or sweating. Therefore, it is generally recommended to gradually taper off the medication under the guidance of a healthcare professional to minimize the risk of withdrawal effects.

Q: Neurontin for dogs – yes or no?

A: Neurontin (gabapentin) can be prescribed for dogs in certain cases, as determined by a veterinarian. The use of Neurontin in dogs is subject to the professional judgment of a veterinarian, who will consider the specific condition being treated and assess the potential benefits and risks.

In veterinary medicine, Neurontin may be utilized to manage certain conditions in dogs, such as chronic pain, neuropathic pain, and seizures. The medication’s mechanism of action, which involves modulating calcium channels and influencing neurotransmitter activity, may help alleviate pain or reduce seizure activity in canine patients.

Q: Is neurontin a good painkiller?

A: Neurontin (gabapentin) can be an effective pain management option for certain individuals, particularly those experiencing neuropathic pain. Its ability to modulate calcium channels and increase the availability of the inhibitory neurotransmitter GABA in the central nervous system can help alleviate pain symptoms.

For many individuals, Neurontin has provided significant relief from neuropathic pain conditions such as diabetic neuropathy, postherpetic neuralgia, and peripheral neuropathy. By targeting the underlying mechanisms contributing to nerve-related pain, Neurontin can help reduce pain intensity and improve overall comfort.

Q: Does neurontin make you sleepy?

A: Yes, Neurontin (gabapentin) has the potential to cause drowsiness and sedation in some individuals. It can induce a calming effect on the central nervous system, leading to feelings of sleepiness or fatigue.

For certain people, Neurontin’s mechanism of action, which involves modulation of calcium channels and enhanced availability of the inhibitory neurotransmitter GABA, may contribute to its sedative properties. This can result in a greater propensity to feel sleepy or experience drowsiness during Neurontin treatment.

Q: Neurontin and alcohol – possible to mix up?

A: Mixing Neurontin (gabapentin) with alcohol is generally not recommended. Both substances can affect the central nervous system, and combining them can potentially lead to increased central nervous system depression, including excessive sedation, drowsiness, and impaired coordination.

Alcohol can enhance the sedative effects of Neurontin, potentially intensifying its drowsiness-inducing properties. This can impair cognitive function, motor skills, and judgment, increasing the risk of accidents and falls. Additionally, alcohol consumption can worsen certain side effects of this drug, such as dizziness and drowsiness.

Q: Does neurontin cause weight gain?

A: Yes, it is. While not everyone may experience this side effect, some users have reported an increase in body weight during the treatment.

Neurontin’s mechanism of action in the brain and nervous system can potentially affect appetite and metabolism, leading to weight gain in certain cases. The exact reasons behind this weight gain are not fully understood, but it may involve alterations in neurotransmitter signaling and changes in energy balance.

Neurontin reviews

Review 1:
Name: Sarah

Neurontin has been a game-changer for me. As someone living with neuropathic pain, it has provided much-needed relief and improved my quality of life. Sarah-approved!

Review 2:
Name: James

Neurontin has been my faithful companion in managing my epilepsy. It has significantly reduced the frequency and severity of my seizures. I can’t imagine life without it. Thank you, Neurontin!

Review 3:
Name: Emily

Neurontin has been a true lifesaver for my restless legs syndrome. I used to toss and turn all night, but now, thanks to Neurontin, my legs are finally at ease, and I can enjoy restful sleep. It’s a miracle!

Review 4:
Name: Michael

I’ve struggled with fibromyalgia for years, but Neurontin has provided much-needed relief from the chronic pain. Michael-approved and grateful for this medication!

Review 5:
Name: Olivia

Neurontin has been a godsend for my anxiety disorder. It has helped me regain control of my life and face challenges with a calm and steady mind. Thank you for bringing peace to my restless thoughts!

Review 6:
Name: Ethan

Living with chronic migraines was unbearable until Neurontin entered my life. It has significantly reduced the frequency and intensity of my migraines, allowing me to get back to the things I love. Ethan gives Neurontin two thumbs up!

Review 7:
Name: Ava

Neurontin has been a revelation for my neuropathic pain. The shooting sensations and burning discomfort have subsided, giving me a new lease on life. Ava-approved and forever grateful!

Review 8:
Name: Benjamin

Neurontin has been my faithful companion in managing my bipolar disorder. It has helped stabilize my moods and alleviate depressive episodes. Benjamin gives Neurontin a standing ovation for its role in his mental well-being!

Disclaimer: The information provided on this website is intended for general knowledge and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The medication should only be taken under the supervision of a qualified healthcare provider. If you experience any of these serious side effects or have any concerns about your health, seek medical attention immediately. The use of any medication, including ED pills, carries risks and benefits that should be carefully weighed and discussed with your healthcare provider. Always seek the advice of a qualified healthcare provider with any questions or concerns you may have about your medical condition or medication.